The Cirque du Soleil founder, along with two professional astronauts from Russia and the United States, lifted off from Russia's Baikonur Cosmodrome in Kazakhstan for the International Space Station. Laliberte flashed a thumbs-up sign during the ascent to orbit.
Laliberte, the world's first "space clown," was cheered by supporters wearing red clown noses when he and his Soyuz crewmates arrived at the launch pad. Canadian Laliberte, NASA's Jeffrey Williams and Russian cosmonaut Maxim Surayev sang the pop song "Mammy Blue" as they climbed into their capsule.
The Soyuz is due to dock with the space station on Friday.
The 50-year-old Canadian tycoon plans a global broadcast from the space station Oct. 9 to promote his One Drop Foundation, which focuses attention on the state of the globe's water resources. Former Vice President Al Gore and Colombian pop star Shakira are among the activists and celebrities expected to contribute to the broadcast, to be shown on the foundation's Web site.
The performance "will be a poem that will be read to the population on Earth in 14 different cities, across five continents," Laliberte said.
"When I first started Cirque du Soleil, I dreamed of seeing all 6 billion people on the planet wearing that little red nose, which for me is symbolic of happiness," he said. "After 25 years, I realize it is not just a question of a clown nose, it is a question of having a glass of clean water every day."
He told reporters he had been tickling his fellow astronauts during training, and planned to tickle them in their sleep aboard the space station as well.
"I'm going there with my sense of humor and my belief that even if sometimes in life we have to do hard work, there is always room to keep humor present," he said.